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NCI Drug Dictionary

  

erlotinib hydrochloride  Patient Information
The hydrochloride salt of a quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:erlotinib
US brand name:Tarceva
Code names:CP-358,774
OSI-774
Chemical structure:N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride