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NCI Drug Dictionary


A cancer vaccine comprised of a recombinant vaccinia viral vector encoding the carcinoembryonic antigen (CEA), MUC-1 (mucin-1), a transmembrane glycoprotein secreted by glandular tissues, and TRICOM, comprised of the three co-stimulatory molecule transgenes B7-1, ICAM-1 and LFA-3. Upon administration, inalimarev may enhance CEA and MUC-1 presentation to antigen presenting cells (APC) and may activate a cytotoxic T lymphocyte (CTL) response against CEA- and MUC-1-expressing tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:recombinant vaccinia-CEA(D609)/MUC1(L93)/TRICOM vaccine
recombinant vaccinia-CEA-MUC1-TRICOM vaccine
rVaccinia-CEA(D609)/MUC1(L93)/TRICOM vaccine
vaccinia-CEA-MUC-1-TRICOM vaccine
US brand name:PANVAC-V