NCI Drug Dictionary
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The hydrochloride salt of an aminoketone antidepressant. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not inhibit monoamine oxidase and, compared to classical tricyclic antidepressants, is a weak blocker of the neuronal uptake of serotonin and norepinephrine. Buproprion also weakly inhibits the neuronal re-uptake of dopamine. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand names:||Amfebutamone |
|Code name:||BW 323U66|
|Chemical structures:||(+-)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone Hydrochloride |