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NCI Drug Dictionary

NCI Drug Dictionary

  

pirarubicin 
An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Tepirubicin
Tetrahydropyranyl-Doxorubicin
theprubicin
THP
THP-Adriamycin
THP-Doxorubicin
Foreign brand names:Pinorubicin
Theprubicine
Therarubicin
Abbreviations:THP-ADM
THP-DOX
Code name:1609RB
Chemical structures:(2"R)-4'-O-Tetrahydropyranyladriamycin
(8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-3-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
[8S-[8Alpha,10alpha(S*)]]-10-[[3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
4'-O-Tetrahydropyranyl Doxorubicin