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NCI Drug Dictionary

  

cytarabine  Patient Information
An antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:arabinofuranosylcytosine
arabinosylcytosine
aracytidine
beta-cytosine arabinoside
cytarabine hydrochloride
cytarabinum
cytosine arabinoside
cytosine arabinosine hydrochloride
US brand names:Cytosar-U
Tarabine PFS
Foreign brand names:Alexan
Arabine
ARA-cell
Aracytin
Aracytine
Cytarbel
Cytosar
Erpalfa
Udicil
Abbreviation:ARA-C
Code names:CHX-3311
U-19920
U-29920A HCl
WR-28453
Chemical structures:1-beta-D-arabinofuranosylcytosine
4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone