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NCI Drug Dictionary

NCI Drug Dictionary

  

staphylococcus aureus protein A 
A protein that resides in the microbial wall of staphylococcus aureus and interferes with opsonization by binding to the Fc portion of immunoglobulin. The protein has a deleterious effect on the epithelial cells that line the respiratory tract, and plays a role in the induction of pneumonia. Protein A also initiates polymorphonuclear cell migration into airway passages via TNFR1 activation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:S. aureus protein A
Staph. Protein A