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NCI Drug Dictionary

  

therapeutic progesterone 
A synthetic form of the endogenous hormone progesterone. Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:progesterone
US brand names:Colprosterone
Gesterol 100
Lipo-Lutin
Lucorteum Sol
Luteohormone
Progestin
Prolutin
Foreign brand names:Corlutina
Corluvite
Cyclogest
Gestiron
Gestone
Lutocyclin
Lutocylin
Lutocylin M
Lutogyl
Lutromone
Progestasert
Progesterol
Progestogel
Progestol
Progeston
Prolidon
Syngesterone
Utrogestan
Abbreviation:PRG
Chemical structure:delta4-pregnene-3,20-dione