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NCI Drug Dictionary

  

clotrimazole 
A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand names:Gyne-Lotrimin
Lotrimin
Mycelex
Mycelex Troche
Abbreviation:CLOT
Chemical structure:1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole