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NCI Drug Dictionary

NCI Drug Dictionary

  

acyclovir 
A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses. After conversion in vivo to the active metabolite acyclovir triphosphate, acyclovir competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the thymidine kinase of HSV. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:acycloguanosine
US brand name:Zovirax
Foreign brand names:Acicloftal
Aclovir
Cargosil
Virorax
Abbreviation:ACV
Code names:BW-248U
Wellcome-248U
Chemical structures:2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
9-[(2-hydroxyethoxy)methyl]guanine