NCI Drug Dictionary
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The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||bisantrene dihydrochloride |
|Foreign brand name:||Zantrene|
|Chemical structures:||9, 10-anthracenedicarboxaldehyde, bis(4, 5-dihydro-1H-imidazol-2-ylhydrazone),dihydrochloride |