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NCI Drug Dictionary


bisantrene hydrochloride 
The hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:bisantrene dihydrochloride
bisantrene HCL
orange crush
Foreign brand name:Zantrene
Code name:CL-216942
Chemical structures:9, 10-anthracenedicarboxaldehyde, bis(4, 5-dihydro-1H-imidazol-2-ylhydrazone),dihydrochloride