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NCI Drug Dictionary


An amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L-alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The clinical use of this agent may be limited by its toxicity profile. MTAP is a key enzyme in the adenine and methionine salvage pathways. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
L-alanosine sodium
Code name:SDX-102
Chemical structures:3-(hydroxynitrosoamino)-L-alanine
L-2-amino-3-(hydroxynitrosoamino)propionic acid
L-2-amino-3-[(N-nitroso)hydroxylamino]propionic acid