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A synthetic triazine analogue of uridine with antimetabolite activity. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di-, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||6-azauracil riboside |
|Chemical structures:||1,2,4-triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl |