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NCI Drug Dictionary

  

povidone-iodine 
An iodophor solution containing a water-soluble complex of iodine and polyvinylpyrrolidone (PVP) with broad microbicidal activity. Free iodine, slowly liberated from the polyvinylpyrrolidone iodine (PVPI) complex in solution, kills eukaryotic or prokaryotic cells through iodination of lipids and oxidation of cytoplasmic and membrane compounds. This agent exhibits a broad range of microbicidal activity against bacteria, fungi, protozoa, and viruses. Slow release of iodine from the PVPI complex in solution minimizes iodine toxicity towards mammalian cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Betadine topical
iodine povidone topical
Povidone-Iodine Solution
US brand names:Betadine
E-Z Prep
E-Z Scrub
Traumasept
Ultradine
Videne
Abbreviation:PVP iodine