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NCI Drug Dictionary

NCI Drug Dictionary

  

cyclosporine 
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:ciclosporin
cyclosporin
cyclosporin A
US brand names:Neoral
Sandimmun
Sandimmune
SangCya
Abbreviations:CsA
CYSP
Code names:27-400
OL 27-400