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NCI Drug Dictionary

NCI Drug Dictionary

  

cyproterone acetate 
The acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:cyproterone
Foreign brand names:Androcur
Andro-Diane
Cyprone
Cyprostat
Dianette
Abbreviations:CPTR
CyPat
Code name:SH 714
Chemical structures:3'H-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)-|
6-chloro-1b,2b-dihydro-17a-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione Acetate
chloro-6-hydroxy-17 alpha methylene-1 alpha, 2 alpha pregnadiene-4,6 dione-3, 20 acetate