In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary

  

dichloromethotrexate 
A chlorinated methotrexate derivative. Dichloromethotrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by the liver. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:dichloroamethopterin
methotrexate, dichloro
Abbreviation:DCM
Chemical structures:3',5'-dichloroamethopterin
3'-5'-dichloromethotrexate
amethopterin, 3',5'-dichloro
glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-
glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-L- (8CI)
L-glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-(9CI)
N-[3,5-dichloro-4-[(2,4-diamino-6-pteridinylmethyl)methylamino]benzoyl] Glutamic Acid