In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary

NCI Drug Dictionary

  

mitoxantrone hydrochloride 
The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:dihydroxyanthracenedione
dihydroxyanthracenedione dihydrochloride
mitoxantrone dihydrochloride
mitoxantrone HCl
mitozantrone
US brand name:Novantrone
Foreign brand names:Mitroxone
Neotalem
Onkotrone
Pralifan
Abbreviations:DHAD
DHAQ
Code name:CL 232315
Chemical structures:1,3-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione
1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone
dihydroxyanthracenedione