NCI Drug Dictionary
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Acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Celiptium|
|Chemical structures:||9-hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium acetate (salt) |