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NCI Drug Dictionary

NCI Drug Dictionary

  

tegafur 
A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand names:Florafur
Fluorofur
Foreign brand names:Citofur
Coparogin
Exonal
Fental
ftorafur
Ftoral
Ftoralon
Fulaid
Fulfeel
Furafluor
Furofutran
Futraful
Lamar
Lifril
Neberk
Nitobanil
Riol
Sinoflurol
Sunfural
Tefsiel
Utefos
Abbreviation:FT
Code names:FT-207
MJF-12264
WR-220066
Chemical structures:5-fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione
5-fluoro-1-(tetrahydro-2-furyl)-uracil
N1-(2'-furanidyl)-5-fluorouracil