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NCI Drug Dictionary

NCI Drug Dictionary

  

norgestrel 
A synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes. This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:D-(-)-Norgestrel
Levonorgestrel
US brand names:Neogest
Ovrette
Foreign brand name:Microlut
Abbreviation:NORGES
Code name:Wy-3707
Chemical structures:(+/-)-13-ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yne-3-one
(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one