NCI Drug Dictionary
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4-nitroestrone 3-methyl ether
A synthetic derivative of estradiol. 4-nitroestrone 3-methyl ether inhibits estrogen sulfotransferase (EST), a progesterone-induced secretory endometrial enzyme which affects estrogen receptor levels. This agent has been shown to be an effective growth inhibitor of some chemically induced animal mammary tumors. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)