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NCI Drug Dictionary

  

spironolactone 
A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Aldactone
Abbreviation:SPL
Code name:SC 9420
Chemical structure:17-hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate