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NCI Drug Dictionary

NCI Drug Dictionary

  

altretamine 
A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Hemel
Hexaloids
US brand names:Hexalen
hexamethylmelamine
Foreign brand names:Hexastat
Hexinawas
Abbreviations:HMM
HXM
Code names:ENT-50852
RB-1515
WR-95704
Chemical structures:2,4,6-tris(dimethylamino)-s-triazine
N,N,N',N',N",N"-hexamethyl-1,3,5-triazine-2,4,6-triamine