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NCI Drug Dictionary

  

ketoconazole 
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand names:Nizoral
Xolegel
Foreign brand names:Fungarest
Fungoral
Ketoderm
Ketoisdin
Orifungal M
Panfungol
Abbreviation:KCZ
Code name:R-41400
Chemical structure:cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine