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NCI Drug Dictionary


A monobenzyl ether of hydroquinone with topical depigmentation activity. Although the exact mechanism of action of depigmentation is unknown, the metabolites of monobenzone appear to have a cytotoxic effect on melanocytes. Furthermore, the depigmentation effect might be mediated through the inhibition of tyrosinase, which is essential in the synthesis of melanin pigments, thereby causing permanent depigmentation of the skin. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:monobenzyl ether of hydroquinone
US brand name:Benoquin