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NCI Drug Dictionary

  

mitoguazone 
A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:methylglyoxal bisguanylhydrazone
mitoguazone dihydrochloride
pyruvaldehyde bis(amidinohydrazone)
Foreign brand name:Zyrkamine
Abbreviations:MeGAG
methyl-G
methyl-GAG
MGBG
MGGH
Code names:DRG-0223
NSC 32946
Chemical structures:1,1'-[(methylethanediylidene)dinitrilo)diguanidine
2,2"-(methyl-1,2-ethanediylidene)bis[hydrazinecarboximidamide]
methylglyoxal bis(amidinohydrazone)