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NCI Drug Dictionary

NCI Drug Dictionary

  

metyrosine 
A methylated tyrosine, a catecholamine synthesis antagonist with antihypertensive property. Metyrosine competitively inhibits tyrosine 3-monooxygenase, an enzyme that activates molecular oxygen to catalyze the hydroxylation of tyrosine to dihydroxyphenylalanine (Dopa), an intermediate to catecholamine (dopamine, norepinephrine, and epinephrine) production. This agent reduces the elevated levels of catecholamines associated with pheochromocytoma, thereby preventing hypertension. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Alpha-methyl-p-tyrosine
methyl-tyrosine
Metirosine
US brand name:DEMSER
Code names:L-588357-0
MK-781