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cisplatin
An inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | CACP cis-DDP cis-diamminedichloro platinum (II) cis-diamminedichloroplatinum Cis-dichloroammine Platinum (II) Cismaplat Cisplatina cis-platinous diamine dichloride cis-platinum cis-platinum II cis-platinum II diamine dichloride CPDD Cysplatyna DDP PDD Peyrone's Chloride Peyrone's Salt Platinoxan platinum diamminodichloride | |
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| US brand names: | | Platinol Platinol-AQ | |
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| Foreign brand names: | | Abiplatin Blastolem Briplatin Cisplatyl Citoplatino Citosin Lederplatin Metaplatin Neoplatin Placis Platamine Platiblastin Platiblastin-S Platinex Platinol- AQ Platinol-AQ VHA Plus Platiran Platistin Platosin | |
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| Abbreviations: | | CDDP DDP | |
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| Chemical structures: | | (SP-4-2)-diamminedichloroplatinum platinum, diaminedichloro-, cis- (8CI) | |
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