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NCI Drug Dictionary

  

peplomycin 
A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:pepleomycin
Abbreviation:PEP
Chemical structures:(S)-n1-[3-[(1-phenylethyl)amino]propyl]bleomycinamide
n1-[3[[(S)-alpha-methylbenzyl]amino]propyl]bleomycinamide