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NCI Drug Dictionary

NCI Drug Dictionary

  

fenretinide 
An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:fenretinimide
Abbreviation:4-HPR
Code name:McN-R-1967
Chemical structures:4-(all-trans-retino-yl)aminophenol
4-hydroxyphenylretinamide
All-trans-4'-hydroxyretinanilide
all-trans-N-(4-hydroxyphenyl)retinamide
all-trans-N-4'-hydroxyretinanilide
N-(4-hydroxyphenyl)retinamide