NCI Drug Dictionary
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A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
actinomycin X 1
|US brand name:||Cosmegen|
|Foreign brand name:||Lyovac Cosmegen|
|Chemical structure:||2-bis[cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3|