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NCI Drug Dictionary

NCI Drug Dictionary

  

trimethoprim-sulfamethoxazole 
A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as co-trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthetase. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:cotrimoxazole
Eslectin
insozalin
trimedin
trimezole
US brand names:Bactrim
Cotrim
Septra
Sulfamethoprim
Sulfatrim
Sulmeprim
Abbreviations:SMZ-TMP
TMP-SMX