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NCI Drug Dictionary

  

vindesine 
A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Compound 112531
deacetyl vinblastine carboxamide
desacetylvinblastine amide
US brand name:Eldisine
Abbreviations:DAVA
DVA
VDS
Code name:Lilly CT-3231
Chemical structure:3-(aminocarbonyl)-O4-deacetyl-3-de-(methoxycarbonyl)vincaleukoblastine