NCI Drug Dictionary
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A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||Compound 112531 |
deacetyl vinblastine carboxamide
|US brand name:||Eldisine|
|Code name:||Lilly CT-3231|