NCI Drug Dictionary
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A synthetic anticoagulant. Warfarin appears to inhibit the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand names:||Athrombin-K |
WARF Compound 42
|Chemical structures:||1-(4'-hydroxy-3'-coumarinyl)-1-phenyl-3-butanone |