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NCI Drug Dictionary

NCI Drug Dictionary

  

cyclophosphamide  Patient Information
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Ciclofosfamida
Ciclofosfamide
Claphene
CP monohydrate
CPM
Cyclophospham
Cyclophosphamid monohydrate
Cyclophosphamidum
Cyclophosphan
Cyclophosphanum
Cytophosphane
Mitoxan
Syklofosfamid
Zytoxan
US brand names:Clafen
Cytoxan
Neosar
Foreign brand names:Carloxan
Cicloxal
Cycloblastin
Cycloblastine
CYCLO-cell
Cyclostin
Cyclostine
Cytophosphan
Endoxan
Endoxana
Enduxan
Fosfaseron
Genoxal
Ledoxina
Procytox
Sendoxan
Abbreviation:CTX
Code names:Asta B 518
B-518
WR-138719
Chemical structures:1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate
2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate
2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate
2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate
2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide
bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate
bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate
N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate
N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate
N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide
N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate
N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate
N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate
N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate