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NCI Drug Dictionary

NCI Drug Dictionary

  

idarubicin hydrochloride 
The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:4-demethoxydaunorubicin
DMDR
idarubicin HCl
US brand name:Idamycin
Foreign brand names:Zavedos
Zavedos
Abbreviations:4-DMDR
IDA
Code names:IMI-30
SC-33428