NCI Drug Dictionary
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A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Ativan|
|Chemical structure:||7-chloro-5-(2-chlorophenyl)-1, 3-dihydro-3-Hydroxy-1,4- benzodiazepin-2-one|