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NCI Drug Dictionary

NCI Drug Dictionary

  

spiroplatin 
A synthetic derivative of cyclohexane sulfatoplatinum with antineoplastic properties. Spiroplatin induces DNA cross-links, thereby inhibiting DNA replication and RNA and protein synthesis. Similar to other platinum compounds, this agent has been shown to be mutagenic and carcinogenic. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code name:TNO-6
Chemical structure:Cis-1,1-diamino-methylcyclohexane sulfato-platinum