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A toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Eulexin|
|Foreign brand names:||Apimid |
|Code name:||Sch 13521|
|Chemical structures:||2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |