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NCI Drug Dictionary

  

flutamide 
A toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Flucinom
Flugerel
Niftolid
US brand name:Eulexin
Foreign brand names:Apimid
Chimax
Drogenil
Euflex
Eulexine
Flucinome
Fluken
Flulem
Flutabene
Flutacan
Fluta-Gry
Flutamex
Flutamin
Flutan
Flutaplex
Fugerel
Grisetin
Oncosal
Profamid
Prostacur
Prostadirex
Prostica
Prostogenat
Tafenil
Tecnoflut
Testotard
Abbreviation:FLUT
Code name:Sch 13521
Chemical structures:2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
4'-nitro-3'-trifluoromethylisobutyranilide
alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide