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A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand names:||Curretab |
|Chemical structures:||(6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione |