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NCI Drug Dictionary

NCI Drug Dictionary

  

hydrocortisone sodium succinate 
The sodium salt of hydrocortisone succinate with glucocorticoid property. Hydrocortisone sodium succinate is chemically similar to the endogenous hormone that stimulates anti-inflammatory and immunosuppressive activities, in addition to exhibiting minor mineralocorticoid effects. This agent binds to intracellular glucocorticoid receptors and is translocated into the nucleus, where it initiates the transcription of glucocorticoid-responsive genes, such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:cortisol sodium succinate
Hycorace
Hydrocortisone 21-Sodium Succinate
Hydrocortisone Na succinate
Nordicort
Sodium hydrocortisone succinate
Solu-Cortef
Solu-Glyc
US brand names:A-Hydrocort
Emergent-EZ
Solu-Cortef
Foreign brand names:Buccalsone
Corlan
Cortop
Efcortelan
Flebocortid
Hidroc Clora
Hydro-Adreson
Hydrocort
Kinogen
Nordicort
Nositrol
Sinsurrene
Solu-Glyc
Abbreviation:HDC
Chemical structure:(11beta)-21-(3-carboxy-1-oxopropyl)-11,17-dihydroxypregn-4-ene-3,20-dione, monosodium salt