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NCI Drug Dictionary

  

ifosfamide  Patient Information
A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Ifomide
Iphosphamid
iphosphamide
Isoendoxan
Iso-Endoxan
isophosphamide
Naxamide
US brand names:Cyfos
Ifex
Ifosfamidum
Foreign brand names:Holoxan
Holoxane
IFO-Cell
Ifolem
Ifomida
Ifoxan
Mitoxana
Tronoxal
Abbreviations:IFF
IFO
IFX
IPP
Code names:Asta Z-4942
MJF-9325
Z-4942
Chemical structures:2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine
3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide
N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide