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NCI Drug Dictionary

  

leuprolide acetate  Patient Information
The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Leuprorelin
Leuprorelin Acetate
US brand names:Lupron
Lupron Depot
Lupron Depot-3 Month
Lupron Depot-4 Month
Lupron Depot-Ped
Viadur
Foreign brand names:Carcinil
Depo-Eligard
Enanton
Enantone
Enantone-Gyn
Ginecrin
Leuplin
Lucrin
Lucrin Depot
Procren
Procrin
Prostap
Trenantone
Uno-Enantone
Abbreviation:LEUP
Code names:A-43818
Abbott 43818
TAP-144
Chemical structures:6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide luteinizing hormone-releasing factor (pig) monoacetate
6-D-leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (pig) monoacetate