In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary

NCI Drug Dictionary

  

zidovudine 
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:azidothymidine
US brand name:Retrovir
Foreign brand name:Aztec
Abbreviations:AZT
ZDV
Code name:BW-A509U
Chemical structure:3'-azido-3'-deoxythymidine