NCI Drug Dictionary
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The dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Quinamed|
|Chemical structure:||1H-benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)|