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NCI Drug Dictionary

NCI Drug Dictionary

  

probenecid 
A benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand names:Benemid
SK-Probenecid
Abbreviation:PROB