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NCI Drug Dictionary

  

diethyldithiocarbamate 
A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Diethylcarbamodithioic Acid
Diethyldione
diethyldithiocarbamic acid
diethyldithiocarbaminic acid
diethyldithione
Foreign brand name:Imuthiol
Abbreviations:DDTC
DIECA
DTC