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NCI Drug Dictionary


pegaspargase  Patient Information
A complex of polyethylene glycol conjugated with L-asparaginase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting these cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. The agent also induces apoptosis in tumor cells. Pegylation decreases the enzyme's antigenicity. Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:L-asparaginase with polyethylene glycol
polyethylene glycol-L-asparaginase
US brand name:Oncaspar
Chemical structure:(monomethoxypolyethylene glycol succinimidyl)74-L-asparaginase