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NCI Drug Dictionary

NCI Drug Dictionary

  

vinorelbine tartrate  Patient Information
The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic activity. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:navelbine ditartrate
vinorelbine ditartrate
US brand name:Navelbine
Foreign brand names:Biovelbin
Eunades
Abbreviations:NVB
VNB
Code name:KW-2307