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NCI Drug Dictionary

NCI Drug Dictionary

  

ganciclovir 
A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:BW 759U
BW-B759U
Nordeoxyguanosine
Foreign brand names:Cymevan
Virgan
Abbreviations:2'NDG
BW-B759U
DHPG
Chemical structures:2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one
2'-Nor-2'-deoxyguanosine
9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine